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Plaques from symptomatic patients and with high vulnerability – characterized by a high lipid and macrophage content, low SMC and collagen content and signs of hemorrhages – showed metabolic alterations in terms of metabolite quantities and transcription levels of metabolic enzymes compared to plaques from asymptomatic patients and with low vulnerability (Tomas et al., 2018)
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Although LYC influences mitochondrial parameters (including redox balance, membrane potential, and apoptotic signaling) these effects are often intertwined with upstream regulatory networks such as Nrf2 and AMPK, as discussed here